By Pascal Schneider (auth.), Michael P. Cancro (eds.)
The BLyS/BAFF relatives of cytokines and receptors has captured and held the eye of B phone biologists over the last decade. Discovery of the 2 ligands and 3 receptors comprising this relatives has yielded a watershed of insights; fostering clean paradigms in our perspectives concerning the differentiation, choice, and homeostatic regulate of almost all B telephone subsets. additionally, simply because those tactics are in detail tied to the mechanistic underpinnings of immune tolerance and activation, elevated figuring out of those actions provides translational development in autoimmunity, neoplasia, and transplantation.
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Additional info for BLyS Ligands and Receptors
18. Allman D, Srivastava B, Lindsley RC. Alternative routes to maturity: branch points and pathways for generating follicular and marginal zone B cells. Immunol Rev 2004;197: 147–60. 19. Cancro MP. Peripheral B-cell maturation: the intersection of selection and homeostasis. Immunol Rev 2004;197:89–101. 20. Hoek KL, Antony P, Lowe J, et al. Transitional B cell fate is associated with developmental stage-specific regulation of diacylglycerol and calcium signaling upon B cell receptor engagement. J Immunol 2006;177(8):5405–13.
In this scenario, BCR signaling modulates BR3, p100, and RelB expression as T1 B cells mature into T2 B cells. Functional expression of BR3 would also induce expression of the BCR co-receptor CD21 , a hallmark of maturation into T2 B cells. In contrast to T1, robust BCR signaling in T2 cells would display enhanced NF-κB signaling, which would lead to further increases in BR3 expression on T2 B cells, thus affording them Fig. 4 Proposed model for the distinct survival potential of T2 compared to T1 B cells.
Enforced bcl-xL gene expression restored splenic B lymphocyte development in BAFF-R mutant mice. J Immunol 2003;170(9):4593–600. 70. Tardivel A, Tinel A, Lens S, et al. The anti-apoptotic factor Bcl-2 can functionally substitute for the B cell survival but not for the marginal zone B cell differentiation activity of BAFF. Eur J Immunol 2004;34(2):509–18. 71. Mackay F, Woodcock SA, Lawton P, et al. Mice transgenic for BAFF develop lymphocytic disorders along with autoimmune manifestations. J Exp Med 1999;190(11): 1697–710.