Immunology

Atlas of Immunology by Julius M. Cruse B.A., B.S., D.Med.Sc., M.D., PH.D.,

By Julius M. Cruse B.A., B.S., D.Med.Sc., M.D., PH.D., F.A.A.M., F.R.S.H., Robert E. Lewis B.S., M.S., Ph.D., F.R.S.H. (auth.)

The Atlas of Immunology is a different pictorial reference, containing greater than one thousand illustrations depicting basically each thought of value in realizing immunology. Diagrams are integrated for all degrees of realizing; there are a few exhibiting uncomplicated rules and others supplying a extra specific therapy for experts. Illustrations within the Atlas diversity from photos of old figures to molecular constructions of lately characterized cytokines, significant histocompatibility complicated molecules, immunoglobulins, and molecules of comparable curiosity to immunologists. No different booklet bargains the breadth or element of illustrated immunological concepts.

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These intensely phagocytic cells contain lysosomes and exert microbicidal action against microbes which they ingest. They also have effective tumoricidal activity. They may take up and degrade both protein and polysaccharide antigens and present them to T lymphocytes in the context of major histocompatibility complex class II molecules. They interact with both T and B lymphocytes in immune reactions. They are frequently found in areas of epithelium, mesothelium and blood vessels. Macrophages have been referred to as adherent cells since they readily adhere to glass and plastic and may spread on these surfaces and manifest chemotaxis.

However, advances in the clarification of their mechanism of action have been facilitated by the use of synthetic oligopeptides with chemotactic activities. The specificity of such compounds depends both on the nature of the amino acid sequence and the position of amino acids in the peptide chain. Methionine at the NH2 terminal is essential for chemotactic activity. Formylation of Met leads to a 3,OOO-30,OOO-fold increase in activity. The second position from the NHz-terminal is also essential and Leu, Phe, and Met in this position are essentially equivalent.

It also degranulates murine neutrophils. The inflammatory activities of MIP-2 are very similar to IL-S. Macrophage cytophilic antibody (Figure 53) is an antibody that becomes anchored to the Fc receptors on macrophage surfaces. This cytophilic antibody can be demonstrated by the immunocytoadherence test. Macrophage functional assays are tests of macrophage function that include (1) chemotaxis: macrophages are placed in one end of a Boyden chamber and a chemoattractant is added to the other end.

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