Immunology

Allergic Diseases: Diagnosis and Treatment (Current Clinical by Phil Lieberman, John A. Anderson

By Phil Lieberman, John A. Anderson

During this up-to-date 3rd variation, specialist physicians gather trouble-free, clinically-oriented publications to help within the day by day administration of the allergic sufferer. With an emphasis on universal allergic ailments and the pharmacological instruments to regulate them, this ebook disseminates the sensible wisdom that practitioners have gathered via perform and instructing. 3 new chapters concentrate on antihistamines, antileukotrienes, and kids experiencing recurrent respiration tract infections. This publication is meant for the front-line health care provider who cares for allergic sufferers. it is going to aid any health practitioner increase the care provided to these sufferers.

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Extra info for Allergic Diseases: Diagnosis and Treatment (Current Clinical Practice)

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An important caveat is that a positive skin test does not prove that allergy is causing the patient’s symptoms. A positive skin test must be correlated with the history to postulate cause and effect. DIAGNOSTIC STUDIES Few blood abnormalities are found in an allergic patient. Eosinophils are often associated with allergy but are rarely increased in allergic rhinitis. More commonly, eosinophils are a peripheral marker of inflammation and are elevated in nonallergic as well as allergic asthma. Eosinophils can be measured by means of an automated complete blood count or a manual total eosinophil count.

Following the immediate skin response, and depending on the dose of allergen and the sensitivity of the patient, there may be a late-phase reaction (LPR). These usually begin at 3–5 h, peak at 6–12 h, and resolve approx 24 h after the immediate response. Clinically, LPRs are characterized by pruritus and edema, often larger than the immediate reaction. Pathologically, LPRs are characterized by local infiltration of inflammatory cells, including neutrophils, monocytes, and eosinophils, into the involved site.

Reporting Results of In Vitro Tests Currently there is no universally agreed-upon standard for reporting the results of tests for allergen-specific IgE antibodies. 4 ng). 35 U/mL, and all results of this value or higher are considered positive. The Chapter 3 / Diagnostic Tests in Allergy 33 Fig. 1. Schematic presentation of an immunosorbent assay for allergen-specific IgE antibody. (A) Allergen represented by small circles and squares has been bound to solid phase. (B) Serum that may contain IgE antibodies specific for the allergen is incubated with the solid phase.

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