Hematology

ABC of Transfusion (ABC Series) by Marcela Contreras

By Marcela Contreras

Blood providers and Transfusion medication became extra medical, medical, good organised and consolidated over the past twenty years. extra is understood concerning the frequency and aetiology of the risks of blood transfusions. The ABC of Transfusion is a good demonstrated creation for all employees operating in blood companies, blood transfusion departments, surgical devices and in depth care, and all prescribers and clients of blood. it's a complete, very popular consultant to all of the sensible points of blood transfusion, together with a number of the issues which may arise.This fourth variation of ABC of Transfusion comprises 5 new chapters on the entire most recent matters together with pre-transfusion trying out, vCJD, stem cellphone transplantation, immunotherapy, and acceptable use of blood - reflecting the truth that transfusion drugs has been revolutionised. invaluable as a realistic consultant, a refresher or for speedy reference, it covers all crucial transfusion concerns and is a perfect resource of data for all health and wellbeing execs concerned with secure and effective use of blood.

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Furthermore, pulmonary infiltration may result in serious morbidity following granulocyte transfusions. Pulmonary infiltration results from antibody-mediated sequestration of white cells in the lungs and presents clinically with fluid overload, pulmonary oedema and exacerbation of pre-existing pulmonary pathology. In the most severe form, the adult respiratory distress syndrome may ensue and patients may require ventilatory and/or cardiovascular support. The development of HLA or HNA alloimmunization in immunosupressed patients receiving granulocytes transfusion is not a common event.

Thrombocytopenia may be the direct consequence of bone marrow infiltration (for example, acute leukaemia), of bone marrow failure due to disease (aplastic anaemia) or of treatment with cytotoxic agents. Platelet transfusions have made potentially curative intensive cytotoxic treatment regimens, with or without stem cell transplantation, possible. Interest in the use of granulocyte transfusions has been renewed due to the increase in numbers of patients with (or at high risk of) fungal infections arising from periods of prolonged neutropenia following more intensive chemotherapy regimens.

Adverse effects of platelet transfusions Most of the adverse effects common to other blood components may also occur following platelet transfusions (see Chapters 11–13). The most common adverse effect of platelet transfusion is the development of immunological reactions such as non-haemolytic febrile transfusion reactions (NHFTRs). Febrile reactions can be caused by white cell antibodies, mainly HLAs, present in the recipient 25 and reacting with donor leucocytes, or, rarely, by interleukins and tumour necrosis factor released by leucocytes present in the platelet concentrate during storage.

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