By Zoltan A. Nagy
A background of contemporary Immunology: A course towards Understanding describes, analyzes, and conceptualizes numerous seminal occasions and discoveries in immunology within the final 3rd of the 20 th century, the period while such a lot questions about the biology of the immune process have been raised and in addition stumbled on their solutions. Written by way of an eyewitness to this heritage, the ebook supplies perception into own points of the real figures within the self-discipline, and its information pushed emphasis on realizing will profit either younger and skilled scientists.
This ebook offers a concise creation to subject matters together with immunological specificity, antibody variety, monoclonal antibodies, significant histocompatibility complicated, antigen presentation, T mobile biology, immunological tolerance, and autoimmune ailment. This vast history of the self-discipline of immunology is a beneficial significant other for college students of immunology, study and scientific immunologists, and examine managers within the pharmaceutical and biotechnology industries.
- Contains the heritage of significant breakthroughs in immunology featured with authenticity and insider details
- Gives an perception into own facets of the gamers within the historical past of immunology
- Enables the reader to acknowledge and choose information of heuristic worth which elucidate very important points of the immune system
- Provides sturdy examples and instructions for the popularity and choice of what's vital for the exploration of the immune system
- Gives transparent separation of descriptive and interpretive components, permitting the reader to tell apart among evidence and research supplied by means of the author
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Additional resources for A History of Modern Immunology. The Path Toward Understanding
Ohno belonged to the great Japanese school of formal genetics, and his famous book Evolution by gene duplication was known by almost everybody. Indeed, I learned more about evolution from this enjoyable and idea-rich book than throughout my entire studies. 12 He has pointed out that natural selection has only hindsight, in that it can only favor already-existing mutants under given environmental conditions, and thus provide a selective advantage for the population as a whole, but never for every member of a population.
1917;26:258. Landsteiner K, Lampl H. Z. Immunitätsforsch. 1917;26:293. Talmage DW. Science 1959;129:1643. Lederberg J. Science 1959;129:1649. Tonegawa S. Nature 1983;302:575. Griffiths GM, Berek C, Kaartinen M, Milstein C. Nature 1984;312:271. Langman RE, Cohn M. Mol. Immunol. 1987;24:675. Cohn M, Langman RE. Immunol. Rev. 1990;115:7. Cohn M. Cell. Immunol. 1997;181:103. Langman RE. Mol. Immunol. 2000;37:555. Percus JK, Percus OE, Perelson AS. Proc. Natl. Acad. Sci. USA 1993;90:1691.
Antibodies distinguish between pathogens to the extent that they discriminate S from NS. According to this concept, specificity can be expressed as a constant, K, which is defined as the probability that a change in recognition would be anti-S. The question then arises: upon what properties is evolution selecting to arrive at a functional K value? Here we have to reiterate that the selection pressure is on the effector response: it must be sufficiently specific to eliminate the pathogen without debilitating the host (S–NS discrimination).